Manufacturer's Manual of Doxorubicin Hydrochloride 25316-40-9

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Adriamycin Hydrochloride / Doxorubicin Hydrochloride / Daunomycin Hydrochloride / Adriamycin / 14-Hydroxydyomycin / Adriamycin / (8S-cis) -10-[(3-Amino-2 , 3,6-Trideoxy-aL-Lesoxhepyranyl) -oxy] -7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-hydroxyacetyl-1- Methoxy-5,12-naphthacene dione hydrochloride / adriamycin / DOX

Cas number 25316-40-9

Molecular formula C27H29NO11 · HCl

Molecular weight 579.98

Doxorubicin hydrochloride

The hydrochloride salt is orange-red needle crystals, soluble in water, DMSO, tetrahydrofuran and alcohol, insoluble in acetone, benzene, chloroform and ether. Solubility in water: 10 mg / mL, the aqueous solution is orange-red transparent solution.

Melting point: 216 ° C

Specific rotation: 248 ° Appearance orange-red powder

Infrared spectrometry matches standard

Melting point 210-216 ° C

Purity≥98.0% (TLC)

Fluorescence λex 470 nm; λem 585 nm (ethanol) Storage temperature: 2-8 ° C

The product uses anti-tumor antibiotics, which has the effect of doxorubicin in cardiac mitochondrial DNA. Reverse transcriptase and RNA polymerase inhibitors, immunosuppressants; can be inserted into the DNA strand. Clinically, it is a cancer chemotherapy agent, mainly used for acute and chronic leukemia and malignant lymphoma.

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