Research Reagents-"Chemical Reviews" reports systematic research results of optical probe design strategy

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"Chemical Reviews" reports the systematic research results of the optical probe design strategy of the chemical laboratory. The optical probe refers to the reaction with the target substance (including coordination, inclusion and group reaction, etc.) and causes optical (absorbance, fluorescence or luminescence) properties Based on these changes, a class of special reagents that allow analysis and determination of target substances. Optical probes can not only improve the sensitivity of analysis, but also greatly improve the spatial and temporal resolution of samples. Therefore, they have been paid attention to for a long time. With the strong support of the National Natural Science Foundation of China, the Ministry of Science and Technology and the Chinese Academy of Sciences, researchers in the Laboratory of In Vitro Analytical Chemistry of the Institute of Chemistry have carried out a series of studies on new optical probes and sensor analysis of biomolecules (Chem. Commun. , 2010, 46, 2560-2562; Chem. Commun., 2011, 47, 8638-8640; Chem. Commun., 2013, 49, 502-504; Chem. Commun., 2013, 49, 5859-5861; Sci. Rep., 2013, 3, 2830; Anal. Chem., 2013, 85, 3926-3932; Anal. Chem., 2013, 85, 6530? 6535; Angew. Chem. Int. Ed., 2012, 51, 6432- 6435); Among them, the optical probe with variable π-conjugated structure was written by Feature Article (2012, 48, 8732-8744) at the invitation of Chem. Commun. Recently, the internationally renowned journal "Chem. Rev." (2014, 114, 590-659) reported the systematic research results of the research group in the optical probe design strategy. In this review paper, based on years of accumulation in the research direction of optical probes, combined with the development trends in this field at home and abroad, the research group summarized and reviewed the design strategy of water-soluble small molecule optical probes, and pointed out Common reaction mechanism for analyte detection. In addition, the article also made specific comments on the advantages and disadvantages of various optical probes and development prospects.

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